Study Identifier

best

Institution & PI(s)

University of North Carolina at Chapel Hill

Protocol Name

The BEST Trial: Biomarkers for Evaluating Spine Treatments (BEST)

Protocol Type

Clinical Trial

Protocol Abstract

The BEST Trial (Biomarkers for Evaluating Spine Treatments) is a NIAMS-sponsored clinical trial being conducted through the NIH HEAL Initiative's Back Pain Consortium (BACPAC) Research Program. The primary objective of this trial is to inform a precision medicine approach to the treatment of Chronic Low-Back Pain by estimating an algorithm for optimally assigning treatments based on an individual's phenotypic markers and response to treatment. Interventions being evaluated in this trial are: (1) enhanced self-care (ESC), (2) acceptance and commitment therapy (ACT), (3) evidence-based exercise and manual therapy (EBEM), and (4) duloxetine. https://clinicaltrials.gov/study/NCT05396014

Study URL